Biotin and derivatives
Medchemexpress LLC Biotin-PEG10-NHS ester | 98.0% | C37H64N4O16S | 25 MG
This PEG-based linker is utilized in the synthesis of degraders, specifically within the PROTAC (Proteolysis Targeting Chimeras) modality. PROTACs are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. They function by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- Intended for research use only
Medchemexpress LLC Bis-PEG9-NHS ester 500mg | 1008402-79-6 | 708.71 | C30H48N2O17 | 500 MG
Bis-PEG9-NHS ester is a PEG9-based bifunctional linker bearing two N-hydroxysuccinimide (NHS) ester groups, designed for amine-targeted bioconjugation and linker applications such as PROTAC and ADC synthesis. It provides a hydrophilic spacer to improve solubility and reduce aggregation during conjugation.
- Bifunctional amine-reactive crosslinker with two NHS ester groups.
- PEG9 spacer increases hydrophilicity and solubility in aqueous media.
- Suitable for PROTAC, ADC, and general bioconjugation to primary amines.
- High chemical purity (≥98%) for reliable conjugation performance.
- Viscous, colorless to light yellow material; moisture sensitive - store sealed and protected from moisture.
- Molecular weight ≈ 708.71 g/mol; molecular formula C30H48N2O17.
eMolecules Mal-PEG11-alcohol | Broadpharm |581.656 | C26H47NO13 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O | 1g | 599128887
Mal-PEG11-alcohol | Broadpharm |581.656 | C26H47NO13 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O | 1g | 599128887
Medchemexpress LLC Nsp-dmae-nhs | 194357-64-7 | 99.5% | 1 MG
NSP-DMAE-NHS is an acridinium ester chemiluminescence reagent containing an N-sulfopropyl group. It is useful in the clinical diagnostics industry, especially in automated immunochemistry analyzers. The product is for research use only and not sold to patients.
- Acridinium ester chemiluminescence reagent
- Contains n-sulfopropyl group
- Useful in the clinical diagnostics industry
- Applicable in automated immunochemistry analyzers
Medchemexpress LLC Azido-PEG3-NHS ester | 1092654-47-1 | ≥98.0% | C12H18N4O7 | 250 MG
Azido-PEG3-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This compound is integral in the development of PROTACs, which harness the ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC Azido-PEG4-NHS-ester | 1807534-82-2 | 96.0% | C14H22N4O8 | 25 MG
Azido-PEG4-NHS-ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent.
- Functions as a click chemistry reagent
- Contains an azide group for chemical reactions
- Engages in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Viscous liquid appearance
- Colorless to light yellow color
Medchemexpress LLC MeCY5-NHS ester triethylamine | 00-00-0 | 96.2% | 777.94 g/mol | C36H40N3KO10S2 | 5 MG
MeCY5-NHS ester (potassium) is an amine-reactive Cy5-family fluorescent dye supplied as the NHS-ester potassium salt for labeling proteins, peptides, and nucleic acids in fluorescence assays and imaging.
- Reactive N-hydroxysuccinimide (NHS) ester for covalent labeling of primary amines.
- Cy5-family near-infrared fluorescence, approx. 649/670 nm excitation/emission.
- Potassium salt form with improved water solubility for aqueous labeling.
- Supplied with analytical documentation, including SDS, COA, 1H NMR, and LC-MS.
- Available in lab-scale quantities suitable for conjugation experiments.
![Medchemexpress LLC Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate | 158913-22-5 | MFCD00083163 | 98.1% | 425.52 | C18H23N3O5S2 | 500MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238859.png-250.jpg)
Medchemexpress LLC Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate | 158913-22-5 | MFCD00083163 | 98.1% | 425.52 | C18H23N3O5S2 | 500MG
SPDP-C6-NHS ester is an alkyl/ether-based PROTAC linker that features an NHS-activated ester for amine coupling and a pyridyldisulfide moiety for disulfide conjugation. Supplied as a white to off-white solid, it is used in conjugation chemistry and the synthesis of PROTACs and related bifunctional molecules.
- Alkyl/ether-based PROTAC linker with an NHS activated ester.
- Contains a pyridyldisulfide group for disulfide bond formation.
- High purity: 98.1%.
- Molecular formula C18H23N3O5S2; molecular weight 425.52.
- Soluble in DMSO at 50 mg/mL; ultrasonic treatment recommended.
- Store powder at -20°C for long term; store solutions at -80°C for short term.
- Available in small-scale solid quantities for research use.
Medchemexpress LLC Biotin-LC-LC-NHS | 89889-52-1 | 98.0% | 567.70 g/mol | C26H41N5O7S | 100 MG
Biotin-LC-LC-NHS is an amino-reactive N-hydroxysuccinimide (NHS) ester used to biotinylate primary amines on proteins, antibodies, and small molecules. It contains an extended LC-LC spacer arm to improve accessibility of the biotin tag and is supplied as a solid for laboratory conjugation and cross-linking applications.
- Reacts with primary amines for stable biotinylation.
- Extended LC-LC spacer improves tag accessibility.
- Provided as a solid, white to light yellow powder.
- Soluble in DMSO at 100 mg/mL; compatible with common in vivo formulation vehicles.
- Store protected from light under nitrogen at -20°C; in solution, store at -80°C for long-term storage.
Medchemexpress LLC GSPT1 protein, human (biotinylated, Avi tag) | 92.0% | 10UG
Recombinant human GSPT1 protein is expressed in Sf9 insect cells and site-specifically biotinylated via an Avi tag. Supplied as a 0.22 μm filtered solution in 50 mM HEPES, pH 7.5, with 1 mM DTT, 200 mM NaCl, and 20% glycerol, the product is provided frozen and shipped on dry ice for storage at -80°C.
- Human-derived sequence spanning residues D2-D637; approx. 70.8 kDa.
- Site-specific Avi biotinylation for consistent streptavidin-based applications.
- High purity (92.0% by reducing SDS-PAGE) suitable for biochemical assays.
- Formulated with glycerol and reducing agent for enhanced stability.
- Available in small-scale sizes to support assay development and screening.
- Shipped on dry ice; recommended long-term storage at -80°C.
![eMolecules 58-85-5 | Biotin | Ambeed | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 50mg | 598441767](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000474061.jpg-250.jpg)
eMolecules 58-85-5 | Biotin | Ambeed | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 50mg | 598441767
Biotin | Ambeed | 58-85-5 | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 50mg | 598441767